M7402

Sigma

 

Magainin II

≥97% (HPLC)

Amino Acid Sequence:Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser
CAS Number:108433-95-0
Linear Formula:C114H180N30O29S
Molecular Weight:2466.90
MDL number:MFCD00133522

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Description

Biochem/physiol ActionsAntibiotic peptide. Magainins are positively charged and amphiphatic. Thought to preferentially bind to anionic phospholipids abundant in bacterial membranes with the formation of dynamic peptide-lipid supramolecular pore and cell permeabilization. Binding to artificial neutral membranes has also been demonstrated.

Properties

assay≥97% (HPLC)
storage temp.−20°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3

References

referenceZasloff, M. Proc. Natl. Acad. Sci. U. S. A. 84, 5449, (1987) Abstract
 Cannon, M. Nature 328, 478, (1987) Abstract
 Giacometti, A., et al., In-vitro activity of cationic peptides alone and in combination with clinically used antimicrobial agents against Pseudomonas aeruginosa. J. Antimicrob. Chemother. 44, 641-645, (1999) Abstract
 Huang, H., Action of antimicrobial peptides: Two-state model. Biochemistry 39, 8347, (2000) Abstract
 Wieprecht, T., Binding of antibacterial magainin peptides to electrically neutral membranes: thermodynamics and structure. Biochemistry 38, 10377, (1999) Abstract
 Giacometti A., et al., In vitro activities of polycationic peptides alone and in combination with clinically used antimicrobial agents against Rhodococcus equi. Antimicrob. Agents Chemother. 43, 2093-2096, (1999) Abstract
 Helmerhorst, E.J., A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides. FEBS Lett. 449, 105, (1999) Abstract
 Matsuzaki K., Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim. Biophys. Acta 1376, 391-400, (1998) Abstract